Traditional Chinese Medicine (TCM) presents a rich and structurally unique knowledge system that challenges conventional applications of large language models (LLMs). Although previous TCM - specific LLMs have shown progress through supervised fine - tuning, they often face limitations in alignment, data quality, and evaluation consistency. In this study, we introduce Ladder - base, the first TCM - focused LLM trained with Group Relative Policy Optimization (GRPO), a reinforcement learning method that improves reasoning and factual consistency by optimizing response selection based on intra - group comparisons. Ladder - base is built upon the Qwen2.5 - 7B - Instruct foundation model and trained exclusively on the textual subset of the TCM - Ladder benchmark, using 80 percent of the data for training and the remaining 20 percent split evenly between validation and test sets. Through standardized evaluation, Ladder - base demonstrates superior performance across multiple reasoning metrics when compared to both state - of - the - art general - purpose LLMs such as GPT - 4, Gemini 2.5, Claude 3, and Qwen3 and domain - specific TCM models including BenTsao, HuatuoGPT2, and Zhongjing. These findings suggest that GRPO provides an effective and efficient strategy for aligning LLMs with expert - level reasoning in traditional medical domains and supports the development of trustworthy and clinically grounded TCM artificial intelligence systems.

Background: Single-Subject Design is used in several areas such as education and biomedicine. However, no suited formal vocabulary exists for annotating the detailed configuration and the results of this type of research studies with the appropriate granularity for looking for information about them. Therefore, the search for those study designs relies heavily on a syntactical search on the abstract, keywords or full text of the publications about the study, which entails some limitations. Objective: To present SSDOnt, a specific purpose ontology for describing and annotating single-subject design studies, so that complex questions can be asked about them afterwards. Methods: The ontology was developed following the NeOn methodology. Once the requirements of the ontology were defined, a formal model was described in a Description Logic and later implemented in the ontology language OWL 2 DL. Results: We show how the ontology provides a reference model with a suitable terminology for the annotation and searching of single-subject design studies and their main components, such as the phases, the intervention types, the outcomes and the results. Some mappings with terms of related ontologies have been established. We show as proof-of-concept that classes in the ontology can be easily extended to annotate more precise information about specific interventions and outcomes such as those related to autism. Moreover, we provide examples of some types of queries that can be posed to the ontology. Conclusions: SSDOnt has achieved the purpose of covering the descriptions of the domain of single-subject research studies.

Large enterprises face many challenges in management of its inventory (Seeloz, 2021). Managing and spot-checking stock is a repetitive process which enables warehouse operatives to miss important data analysis of company's stock which can result a negative impact on the business. Warehouse companies today have identified two major issues: obstacles in business planning and high operational budget costs (Fedyk, 2020). The overabundance of data and tracking issues can become resolute. Using machine learning, algorithms and other dimensions of Artificial Intelligence (AI), new insights, better regulated inventory, and successful operations of a warehouse can be accomplished.

Deepfake technology (DT) has taken a new level of sophistication. Cybercriminals now can manipulate sounds, images, and videos to defraud and misinform individuals and businesses. This represents a growing threat to international institutions and individuals which needs to be addressed. This paper provides an overview of deepfakes, their benefits to society, and how DT works. Highlights the threats that are presented by deepfakes to businesses, politics, and judicial systems worldwide. Additionally, the paper will explore potential solutions to deepfakes and conclude with future research direction.